crisprking/nka-pump-genomics

This repository is a reproducible genomics analysis of disease-associated variants in Na⁺/K⁺-ATPase subunits. Its principal workflow gathers and aligns sequences, derives conservation, maps and validates ClinVar variants, adds population and predictor evidence, then tests biological associations and produces reports. The graph preserves documented structure, topology, paralogue and classifier analyses as capabilities. Sampled source confirms the variant, population and statistical wiring; connections for unsampled pipeline stages are limited to documented inputs and outputs rather than inferred from their numbering.